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Detection of somatic variants in peripheral blood lymphocytes using a next generation sequencing multigene pan cancer panel.

Cancer genetics - 1 Feb 2017

Coffee Bradford, Cox Hannah C, Kidd John, Sizemore Scott, Brown Krystal, Manley Susan, Mancini-DiNardo Debora

Abstract excerpt

Next Generation Sequencing (NGS) multigene panels, which are routinely used to assess hereditary cancer risk, can detect both inherited germline variants and somatic variants in cancer-risk genes. We evaluated the frequency and distribution of likely somatic Pathogenic and Likely Pathogenic variants (PVs) detected in >220,000 individuals who underwent clinical testing with a 25-gene panel between September 2013...

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Identifiers

PMID: 28279308
DOI: 10.1016/j.cancergen.2017.01.002

Genes

ATM
CHEK2

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