Article

Detection of Rare Germline Variants in the Genomes of B Cell Neoplasms

2021-01-18

Abstract excerpt

Growing evidence has revealed the implication of germline variation in cancer predisposition and prognostication. Here, we describe an analysis of putatively disruptive rare variants across the genomes of 726 patients with B-cell lymphoid neoplasms. We discovered a significant enrichment of 26 genes in germline protein truncating variants (PTVs), affecting cell signaling (MET, JAK2, ANGPT2), energy metabolism (ACO...

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Literature Corpus work: bf7d9d27-140e-506e-a566-381f51e2638d
DOI: 10.20944/preprints202101.0330.v1

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