Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.

doi:10.1038/s41375-021-01246-w

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Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.

Leukemia - 1 Nov 2021

Singhal Deepak, Hahn Christopher N, Feurstein Simone, Wee Li Yan A, Moma Luke, Kutyna Monika M, Chhetri Rakchha, Eshraghi Leila, Schreiber Andreas W, Feng Jinghua, Wang Paul P-S, Babic Milena, Parker Wendy T, Gao Song, Moore Sarah, Das Soma, Thomas David, Pattnaik Swetansu, Brown Anna L, D'Andrea Richard J, Poplawski Nicola K, Thomas Daniel, Scott Hamish S, Godley Lucy A, Hiwase Devendra K

Abstract excerpt

The majority of studies assessing the contribution of pathogenic germline variants (PGVs) to cancer predisposition have focused on patients with single cancers. We analyzed 45 known cancer predisposition genes (CPGs) in germline samples of 202 patients with hematological malignancies (HMs) plus one or more other independent cancer managed at major tertiary medical centers on two different continents. This...

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PMID: 33850299
DOI: 10.1038/s41375-021-01246-w

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