Investigating the influence of germline ATM variants in chronic lymphocytic leukemia on cancer vulnerability.

doi:10.3324/haematol.2024.286031

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Article

Investigating the influence of germline ATM variants in chronic lymphocytic leukemia on cancer vulnerability.

Haematologica - 1 Apr 2025

Azevedo Roberta S, Morelli Francesca, Mashima Kiyomi, Fardoun Rayan, Tyekucheva Svitlana, Fernandes Stacey, Shupe Samantha, Terra Marissa, Patel Anisha, Davids Matthew S, Yu Joseph, Brown Jennifer R

Abstract excerpt

Chronic lymphocytic leukemia (CLL) patients have an increased risk of secondary cancers, along with predisposition to CLL in their relatives. We have previously identified germline ATM variants as associated with CLL risk. Here, we present their impact on predisposition to secondary neoplasms in CLL patients and their relatives. Patients enrolled in our tissue bank who had germline ATM status available were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39568439
DOI: 10.3324/haematol.2024.286031
PMCID: PMC11959239

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