Article
SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years.
Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2024
Rowntree Louise C, Audsley Jennifer, Allen Lilith F, McQuilten Hayley A, Hagen Ruth R, Chaurasia Priyanka, Petersen Jan, Littler Dene R, Tan Hyon-Xhi, Murdiyarso Lydia, Habel Jennifer R, Foo Isabelle J H, Zhang Wuji, Ten Berge Elizabeth R V, Ganesh Hanujah, Kaewpreedee Prathanporn, Lee Kelly W K, Cheng Samuel M S, Kwok Janette S Y, Jayasinghe Dhilshan, Gras Stephanie, Juno Jennifer A, Wheatley Adam K, Kent Stephen J, Rossjohn Jamie, Cheng Allen C, Kotsimbos Tom C, Trubiano Jason A, Holmes Natasha E, Pang Chan Ken Ka, Hui David S C, Peiris Malik, Poon Leo L M, Lewin Sharon R, Doherty Peter C, Thevarajan Irani, Valkenburg Sophie A, Kedzierska Katherine, Nguyen Thi H O
Abstract excerpt
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-CoV-2-specific T cell responses are of key importance for viral clearance and COVID-19 recovery. However, in long COVID, the establishment and persistence of SARS-CoV-2-specific T...
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