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Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk.

Investigative ophthalmology & visual science - 1 Apr 2025

Song Wei-Qi, Zhong Wen-Fang, Li Zhi-Hao, Liu Dan, Ren Jiao-Jiao, Shen Dong, Gao Jian, Chen Pei-Liang, Yang Jin, Wang Xiao-Meng, You Fang-Fei, Li Chuan, Chen Huan, Xie Jia-Hao, Mao Chen

Abstract excerpt

Purpose: To evaluate the association of biological age acceleration with incident glaucoma risk and examine whether genetic predisposition modifies it. Methods: We included 318,556 UK Biobank participants without baseline glaucoma. Biological age was calculated using the Klemera-Doubal method Biological Age (KDM-BA) and PhenoAge algorithms. Hazard ratios (HRs) and 95% confidence intervals (CIs) of the association...

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PMID: 40244607
DOI: 10.1167/iovs.66.4.47
PMCID: PMC12013680

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