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Article

Biological age acceleration and interaction with genetic predisposition in the risk of type 2 diabetes and coronary artery disease.

GeroScience - 1 Feb 2026

Yang Guangrui, Du Xihao, Jiang Xuanwei, Wang Jingxuan, Shi Shuxiao, Zhong Victor W

Abstract excerpt

Biological age (BA), compared to chronological age, offers a more accurate reflection of aging status. In this prospective UK Biobank study, BA acceleration was measured using the Klemera-Doubal method BA (KDM-BA) and Phenotypic age (PhenoAge). Cox models estimated associations of BA acceleration with incident T2D (n = 271,885) and CAD (n = 270,054). Both additive and multiplicative interactions between BA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40299261
DOI: 10.1007/s11357-025-01671-0
PMCID: PMC12972435

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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