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Article

Accelerated Biological Aging and Genetic Pleiotropy in Age-Related Eye Diseases: A Population-Based Cohort and Integrative Genetic Analysis.

Investigative ophthalmology & visual science - 3 Nov 2025

Gao Yuelan, Wang Yuyao, Zhang Yuzhou, Yu Jun, Xu Jianming, Kam Ka Wai, Ho Mary, Young Alvin L, Pang Chi Pui, Tham Clement C, Yam Jason C, Chen Li Jia

Abstract excerpt

Purpose: Age-related eye diseases (AREDs) are major causes of vision loss worldwide. Biological age acceleration (BAA) reflects systemic aging, but its relationship with AREDs and underlying genetic mechanisms remains unclear. This study investigated the combined effects of BAA and genetic risk on AREDs and blindness, and explored shared genetic pathways and potential anti-aging targets. Methods: Biological age...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41196129
DOI: 10.1167/iovs.66.14.14
PMCID: PMC12599516

Genes

APOC1
APOE
BCAM
TOMM40

Provenance

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