Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes.

doi:10.1186/s13148-024-01723-w

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Article

Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes.

Clinical epigenetics - 14 Aug 2024

Chen Jiawei, Yuan Xiang-Ling, Zhou Xiaoyu, Xu Jiahao, Zhang Xinyue, Duan Xuanchu

Abstract excerpt

BACKGROUND: Age-related eye diseases (AREDs) have become increasingly prevalent with the aging population, serving as the leading causes of visual impairment worldwide. Epigenetic clocks are generated based on DNA methylation (DNAm) levels and are considered one of the most promising predictors of biological age. This study aimed to investigate the bidirectional causal association between epigenetic clocks and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39143611
DOI: 10.1186/s13148-024-01723-w
PMCID: PMC11325616

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