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Article

Phenotypic age acceleration and genetic risk synergistically increase age-related eye disease risk in the UK Biobank.

Scientific reports - 3 Jul 2026

Yuan Haoyu, Hu Yuxiang

Abstract excerpt

To evaluate the independent and synergistic effects of phenotypic age acceleration (PhenoAgeAccel) and genetic risk on age-related eye diseases (AREDs). We analyzed 395,322 participants from the UK Biobank to assess the association between PhenoAgeAccel and polygenic risk scores for age-related macular degeneration (AMD) and age-related cataract (ARC). Cox proportional hazards models evaluated independent effects...

Read the complete abstract on PubMed

Topics

Humans
United Kingdom
Phenotype
Genetic Predisposition to Disease
Genetic Risk Score
Cataract
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macular Degeneration

Aged

Male

Risk Factors

UK Biobank

Aging

Biological Specimen Banks

Middle Aged

Proportional Hazards Models

Source

Open in PubMed Open full text

Identifiers

PMID: 42399507
DOI: 10.1038/s41598-026-60932-w
PMCID: PMC13530156

Genes

ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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