Article
Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas.
Cell genomics - 14 May 2025
Mahyari Eisa, Boggy Gregory J, McElfresh G W, Kaza Maanasa, Benjamin Sebastian, Varco-Merth Benjamin, Ojha Sohita, Feltham Shana, Goodwin William, Nkoy Candice, Duell Derick, Selseth Andrea, Bennett Tyler, Barber-Axthelm Aaron, Smedley Jeremy V, Labriola Caralyn S, Axthelm Michael K, Reeves R Keith, Okoye Afam A, Hansen Scott G, Picker Louis J, Bimber Benjamin N
Abstract excerpt
Single-cell RNA sequencing (scRNA-seq) allows cell classification using genome-wide transcriptional state; however, high-dimensional transcriptomic profiles, and the unsupervised analyses employed to interpret them, provide a systematically different view of biology than well-established functional/lineage definitions of immunocytes. Understanding these differences and limits is essential for accurate...
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