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MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

21 Mar 2024

Abstract excerpt

Abstract Mitochondrial Ca 2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca 2+ influx across the sarcolemma that causes mitochondrial Ca 2+ overload, organelle rupture, and muscle necrosis. The mitochondrial Ca 2+ uniporter (MCU) complex is the primary characterized mechanism for acute...

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PMID: 38514795
DOI: 10.1038/s41598-024-57340-3

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