Article
An inducible FOXL2-dependent mouse model of ovarian adult type granulosa cell tumor.
Gynecologic oncology - 1 Mar 2025
Li Jian, Welte Thomas, Calzoncinth Katherine, Vuttaradhi Veena K, Brodsky Allison L, Wong Kwong-Kwok, Sebastian Manu M, Lawson Barrett, Kingsley Charles V, Hillman R Tyler
Abstract excerpt
BACKGROUND: Adult-type granulosa cell tumors (AGCTs) are rare ovarian sex cord/stromal tumors with near-universal hotspot mutations in FOXL2 (c.C402G; p.Cys134Trp). Progress in the treatment of relapsed AGCT has been hindered by the lack of high-fidelity FOXL2-based mouse models. To address this critical unmet need, we created and validated a genetically engineered inducible mouse model of the human FOXL2...
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