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Article

Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Nov 2024

Nagy Agnes, Niu Na, Ratner Elena, Hui Pei, Buza Natalia

Abstract excerpt

Adult granulosa cell tumor, the most common malignant ovarian sex cord-stromal tumor, harbors the characteristic mutation c.402C>G (p.C134W) in the FOXL2 gene in ~90% to 95% of cases. To date, no other variants of FOXL2 mutations have been identified in these tumors. Here we report the first case of an adult granulosa cell tumor with a novel FOXL2 point mutation c.398C>T (p.A133V) presenting in a 64-year-old...

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PMID: 38426544
DOI: 10.1097/PGP.0000000000001024

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Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications.PMID 38426544Read ↗

Adult-Type Granulosa Cell Tumors and FOXL2 MutationSemantic proximity Read ↗

Mutation of FOXL2 in granulosa-cell tumors of the ovary.Semantic proximity Read ↗

Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease.Semantic proximity Read ↗

The FOXL2 mutation (c.402C>G) in adult-type ovarian granulosa cell tumors of three Japanese patients: clinical report and review of the literature.Semantic proximity Read ↗

FOXL2 Mutation Analysis of Ovarian Sex Cord-Stromal Tumors: Genotype-Phenotype Correlation With Diagnostic Considerations.Semantic proximity Read ↗

FOXL2 mutations in granulosa cell tumors occurring in males.Semantic proximity Read ↗

The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.Semantic proximity Read ↗

Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation.Semantic proximity Read ↗

Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors.Semantic proximity Read ↗

Large Ovarian Follicle Cyst: Benign Mimic of Cystic Adult Granulosa Cell Tumor.Semantic proximity Read ↗

FOXL2 Mutation Status in Sex Cord-stromal Tumors Cannot be Predicted by Morphology.Semantic proximity Read ↗

FOXL2 mutation is absent in uterine tumors resembling ovarian sex cord tumors.Semantic proximity Read ↗

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