APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos.

doi:10.1002/alz.70138

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Article

APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025

Barral Sandra, Yang Zikun, Phillips Nicole, Barber Robert C, Brickman Adam M, Honig Lawrence S, Cieza Basilio, Reyes-Dumeyer Dolly, Mayeux Richard, Rajabli Farid, Cuccaro Michael L, Vance Jeffery M, Arango Silvia Mejia, Samper-Ternent Rafael, Obregon Alejandra Michaels, Montesinos Rosa, Soto-Añari Marcio, Duran Juan Carlos, Cusicanqui Maria, Velazquez Ivonne Z Jimenez, Marca Victoria, Illanes-Manrique Maryenela, Cornejo-Olivas Mario, Pericak-Vance Margaret, Wong Rebeca, O'Bryant Sid, Custodio Nilton, Tosto Giuseppe

Abstract excerpt

BACKGROUND: Effect of apolipoprotein E (APOE) on Alzheimer's disease and related dementias (ADRD) risk is heterogeneous across populations, with scarce data on Hispanics/Latinos. METHODS: APOE genotype was studied in 12,221 Hispanics/Latinos (per cohort and via metanalysis): Caribbean-Hispanics, Mexicans, Mexican-Americans, and Peruvians/Bolivians. A subsample had longitudinal assessment and plasma p-tau. We...

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PMID: 40219824
DOI: 10.1002/alz.70138
PMCID: PMC11992591

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APOE

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