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Article

Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Orellana Paulina, Caviedes Ariel, Gonzalez Liset, Ochoa-Rosales Carolina, Carmona Danilo, González-Silva Carolina, Hernández Hernán, Britton Gabrielle B, Villarreal Alcibiades E, Campos Victoria, Hendrie Hugh, Acosta-Uribe Juliana, Pina-Escudero Stefanie D, Yokoyama Jennifer S, Vilor-Tejedor Natalia, Parra Mario, Santamaria-García Hernando, Ibañez Agustín, de la Cruz Rolando, Duran-Aniotz Claudia

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele represents the strongest genetic risk factor for Alzheimer's disease (AD), but its role in genetically diverse Latin American and Caribbean (LAC) populations is underexplored. We conducted a meta-analysis of 35 studies from 11 LAC countries, encompassing 3206 patients with AD and 5515 controls. The ε4 allele demonstrated significant association with increased AD risk (odds...

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Identifiers

PMID: 41724662
DOI: 10.1002/alz.71224
PMCID: PMC12927995

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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