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Article

The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme.

International journal of molecular sciences - 11 Jan 2022

Ezquerra-Aznárez José Manuel, Degiacomi Giulia, Gašparovič Henrich, Stelitano Giovanni, Sammartino Josè Camilla, Korduláková Jana, Governa Paolo, Manetti Fabrizio, Pasca Maria Rosalia, Chiarelli Laurent Roberto, Ramón-García Santiago

Abstract excerpt

Avermectins are macrocyclic lactones with anthelmintic activity. Recently, they were found to be effective against Mycobacterium tuberculosis, which accounts for one third of the worldwide deaths from antimicrobial resistance. However, their anti-mycobacterial mode of action remains to be elucidated. The activity of selamectin was determined against a panel of M. tuberculosis mutants. Two strains carrying...

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Identifiers

PMID: 35054958
DOI: 10.3390/ijms23020771
PMCID: PMC8776228

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