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Article

Isolation and characterization of compound-resistant isolates of Mycobacterium tuberculosis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

O'Malley Theresa, Melief Eduard

Abstract excerpt

This chapter describes the isolation and characterization of spontaneous resistant mutants of Mycobacterium tuberculosis. The overall objective of resistant mutant isolation is to determine the mode of action and/or cellular targets of new antimycobacterial agents. Whole-genome sequencing of resistant mutants can identify targets of antimycobacterial drugs and mechanisms of resistance, such as efflux, changes in...

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PMID: 25779325
DOI: 10.1007/978-1-4939-2450-9_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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