Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus.

Microbiology spectrum - 23 Feb 2022

Aragaw Wassihun Wedajo, Cotroneo Nicole, Stokes Suzanne, Pucci Michael, Critchley Ian, Gengenbacher Martin, Dick Thomas

Abstract excerpt

The aminobenzimidazole SPR719 targets DNA gyrase in Mycobacterium tuberculosis. The molecule acts as inhibitor of the enzyme's ATPase located on the Gyrase B subunit of the tetrameric Gyrase A2B2 protein. SPR719 is also active against non-tuberculous mycobacteria (NTM) and recently entered clinical development for lung disease caused by these bacteria. Resistance against SPR719 in NTM has not been characterized....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Benzimidazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Gyrase

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Mycobacterium avium

Share to Mycobacterium Infections, Nontuberculous

Share to Topoisomerase II Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 35019671
DOI: 10.1128/spectrum.01321-21
PMCID: PMC8754139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus.PMID 35019671Read ↗

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.Semantic proximity Read ↗

In Vitro Susceptibility Testing of a Novel Benzimidazole, SPR719, against Nontuberculous MycobacteriaSemantic proximity Read ↗

Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous MycobacteriaSemantic proximity Read ↗

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus.Semantic proximity Read ↗

Mycobacterium abscessus: a new antibiotic nightmareSemantic proximity Read ↗

Bedaquiline- and clofazimine- selected Mycobacterium tuberculosis mutants: further insights on resistance driven largely by Rv0678Semantic proximity Read ↗

MarR-Dependent Transcriptional Regulation of <i>mmpSL5</i> induces Ethionamide Resistance in <i>Mycobacterium abscessus</i>Semantic proximity Read ↗

Mycobacterium tuberculosis DNA Gyrase as a Target for Drug DiscoverySemantic proximity Read ↗

Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex.Semantic proximity Read ↗

Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessusSemantic proximity Read ↗

Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessusSemantic proximity Read ↗

Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.