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Click Lipid Nanoparticles for the Delivery of mRNA to Metabolically Labeled Cancer Cells

4 Apr 2025

Abstract excerpt

Lipid nanoparticle (LNP)-based mRNA delivery has a lot of potential in combating a wide range of diseases, but delivering mRNA to specific cell types continues to be challenging. Despite recent advances in organ and cell specificity, the majority of clinical LNP systems cannot fully release their payload to a targeted site. Incorporating active targeting moieties into LNPs is highly desired to expand nanomedicine...

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PMID: 40181500
DOI: 10.1021/acs.biochem.4c00699

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