Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chimeric Antigen Receptor-Engineered Cell Membrane-Coated Nanoparticles Promote Dual-Targeted mRNA-Based Cancer Gene Therapy

14 Apr 2025

Abstract excerpt

Gene therapy using mRNA has facilitated progress in cancer therapy. However, its application is hindered by a limited tumor-targeted delivery approach, leading to off-target effects and safety concerns. Chimeric antigen receptor (CAR) molecules enable T cells to recognize specific antigens in a major histocompatibility complex-unrestricted manner. CAR approaches provide an “off-the-shelf” solution for introducing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to CAR-T cell therapy research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40227438
DOI: 10.1021/acsnano.4c18153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chimeric Antigen Receptor-Engineered Cell Membrane-Coated Nanoparticles Promote Dual-Targeted mRNA-Based Cancer Gene TherapyPMID 40227438Read ↗

From structural design to delivery: mRNA therapeutics for cancer immunotherapySemantic proximity Read ↗

Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and <i>in vivo</i> CAR T-cell engineeringSemantic proximity Read ↗

mRNA vaccines in tumor targeted therapy: mechanism, clinical application, and development trendsSemantic proximity Read ↗

mRNA‐based chimeric antigen receptor T cell therapy: Basic principles, recent advances and future directionsSemantic proximity Read ↗

Nanoparticle-mediated mRNA delivery to TNBC PDX tumorsSemantic proximity Read ↗

Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell GenerationSemantic proximity Read ↗

Ligand conjugated lipid-based nanocarriers for cancer theranosticsSemantic proximity Read ↗

mRNA in cancer immunotherapy: beyond a source of antigenSemantic proximity Read ↗

TROP2-targeting chimeras (TRTACs) for tumor-selective membrane protein degradation and enhanced drug deliverySemantic proximity Read ↗

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptorSemantic proximity Read ↗

From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumorsSemantic proximity Read ↗

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.