Article

Reengineering mRNA lipid nanoparticles for systemic delivery to pancreas

2024-11-03

Abstract excerpt

Lipid nanoparticles (LNPs) hold transformative potential for nucleic acid delivery, with applications ranging from clinical use, particularly in COVID-19 vaccines, to gene therapy and cancer immunotherapy. Traditional LNPs are composed of four components: ionizable lipids, cholesterol, helper lipids, and PEGylated lipids. However, a significant hurdle remains the need for more efficient and selective systemic deli...

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Literature Corpus work: eb7ee052-3a64-515d-afaa-9be18501ad09
DOI: 10.1101/2024.10.30.621163

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