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Xuefu Zhuyu decoction attenuates thoracic aortic dissection by regulating VSMC phenotypic switching and oxidative stress via the JAK2/STAT3/HIF-1α pathway.

Journal of ethnopharmacology - 10 May 2026

Cheng-Wen Li, Rong Gao, Yi-Fan Jiang, Shou-Jia Wang, Si-Yi Li, Chun-Yan Li, Fan Liang, Xiao-Qiang Li, Wei-Xun Duan, Fan Song

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Xuefu Zhuyu Decoction (XFZY), a classic formula for "blood stasis syndrome", has insufficient evidence for its thoracic aortic dissection (TAD) therapeutic efficacy and its underlying mechanism remains unclear. AIM OF STUDY: This study aimed to elucidate the efficacy, mechanism, and key components of XFZY against TAD. MATERIAL AND METHOD: Using a β-Aminopropionitrile (BAPN)-induced...

Topics

Animals
STAT3 Transcription Factor
Hypoxia-Inducible Factor 1, alpha Subunit
Oxidative Stress
Drugs, Chinese Herbal
Male
Janus Kinase 2
Mice
Signal Transduction
Dissection, Thoracic Aorta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Docking Simulation

Mice, Inbred C57BL

Aortic Dissection

Disease Models, Animal

Phenotype

Source

Identifiers

PMID: 41679360
DOI: 10.1016/j.jep.2026.121324

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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