Article
Genetically personalised organ-specific metabolic models in health and disease
2022-03-31
Abstract excerpt
Understanding how genetic variants influence disease risk and complex traits (variant-to-function) is one of the major challenges in human genetics. Here we present a model-driven framework to leverage human genome-scale metabolic networks to define how genetic variants affect biochemical reaction fluxes across major human tissues, including skeletal muscle, adipose, liver, brain and heart. As proof of concept, we...
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Identifiers and source
- Literature Corpus work
- 633a65cc-0f33-5a0b-922e-534fe4a333d9
- DOI
- 10.1101/2022.03.25.22272958