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CRISPR/Cas9-induced breaks are insufficient to break linkage drag surrounding the ToMV locus of Solanum lycopersicum.

G3 (Bethesda, Md.) - 4 Jun 2025

Grubben Jillis, Bijsterbosch Gerard, Aktürk Burak, Visser Richard G F, Schouten Henk J

Abstract excerpt

Despite the success of CRISPR/Cas9 in inducing DNA double-strand breaks for genome editing, achieving targeted recombination in somatic cells remains challenging, particularly at recombination cold spots like the tomato mosaic virus (ToMV) resistance locus in Solanum lycopersicum. We investigated the potential of CRISPR/Cas9-induced targeted recombination in somatic cells to overcome linkage drag surrounding the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40172925
DOI: 10.1093/g3journal/jkaf068
PMCID: PMC12159746

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