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Article

Ultrasensitive Detection of FLT3-ITD Mutations via Primer Competition Enhanced Mutant Accumulation.

Analytical chemistry - 15 Apr 2025

Dai Ling, Deng Mengjun, Chen Kena, Chen Xueping, Li Junjie

Abstract excerpt

The in-frame internal tandem duplication of the FLT-3 gene (FLT3-ITD), a prevalent genetic aberration, significantly contributes to treatment failure and poor prognosis in acute myeloid leukemia (AML). A robust and cost-effective assay for minimal residual disease (MRD) detection in FLT3-ITD+ AML is crucial for guiding therapeutic decisions. However, current MRD monitoring methodologies for FLT3-ITD+ patients are...

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Identifiers

PMID: 40162954
DOI: 10.1021/acs.analchem.4c04750

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FLT3

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