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Article

FLT3-TKD Measurable Residual Disease Detection Using Droplet Digital PCR and Clinical Applications in Acute Myeloid Leukemia.

International journal of molecular sciences - 26 May 2024

Li Eric Wenlong, Tran Ngoc Yen Kim, McCulloch Derek, Krigstein Michael, Catalano Alberto, Othman Jad, Abadir Edward, Smith Cheryl, Iland Harry

Abstract excerpt

The tyrosine kinase domain of the FMS-Like tyrosine kinase 3 (FLT3-TKD) is recurrently mutated in acute myeloid leukemia (AML). Common molecular techniques used in its detection include PCR and capillary electrophoresis, Sanger sequencing and next-generation sequencing with recognized sensitivity limitations. This study aims to validate the use of droplet digital PCR (ddPCR) in the detection of measurable...

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Identifiers

PMID: 38891959
DOI: 10.3390/ijms25115771
PMCID: PMC11171966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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