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Article

Aberrant p53 immunostaining patterns in breast carcinoma of no special type strongly correlate with presence and type of TP53 mutations.

Virchows Archiv : an international journal of pathology - 1 Oct 2024

Armbruster Hannes, Schotte Tilman, Götting Isabell, Overkamp Mathis, Granai Massimo, Volmer Lea Louise, Bahlinger Veronika, Matovina Sabine, Koch André, Dannehl Dominik, Engler Tobias, Hartkopf Andreas D, Brucker Sara Y, Bonzheim Irina, Fend Falko, Staebler Annette, Montes-Mojarro Ivonne

Abstract excerpt

Recent studies have revealed an association between TP53 mutations and endocrine resistance in hormone receptor-positive, HER2-negative breast cancer (HR + HER2 -BC). Aberrant p53 immunostaining (IHC) patterns may provide a surrogate marker for TP53 mutations. Building upon a ternary algorithm of aberrant staining patterns, this study evaluates the reliability of p53 IHC as screening tool for TP53 mutations in BC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39191994
DOI: 10.1007/s00428-024-03897-3
PMCID: PMC11522169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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