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Article

Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations.

Psychological medicine - 31 Mar 2025

Al-Soufi Laila, Hindley Guy, Rødevand Linn, Shadrin Alexey A, Jaholkowski Piotr, Fominykh Vera, Icick Romain, Tesfaye Markos, Costas Javier, Andreassen Ole A

Abstract excerpt

BACKGROUND: Externalizing and internalizing pathways may lead to the development of substance use behaviors (SUBs) and substance use disorders (SUDs), which are all heritable phenotypes. Genetic correlation studies have indicated differences in the genetic susceptibility between SUBs and SUDs. We investigated whether these substance use phenotypes are differently related to externalizing and internalizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40162501
DOI: 10.1017/S0033291725000108
PMCID: PMC12094651

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