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Phylodynamic assessment of SNP distances from whole genome sequencing for determining Mycobacterium tuberculosis transmission

28 Mar 2025

Abstract excerpt

The global tuberculosis (TB) epidemic is driven by primary transmission. Pathogen genome sequencing is increasingly used in molecular epidemiology and outbreak investigations. Based on contact tracing and epidemiological links, Single Nucleotide Polymorphism (SNP) cut-offs, ranging from 3 to 12 SNPs, identify probable transmission clusters or exclude direct transmission. However, contact tracing can be limited by...

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PMID: 40155671
DOI: 10.1038/s41598-025-94646-2

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