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Article

Molecular Epidemiology of Mycobacterium tuberculosis Across 3 Distinct Geographic Sites in South Africa.

The Journal of infectious diseases - 15 Oct 2025

Ryckman Theresa S, Hopkins Lincoln, Tang Linrui, Biché Patrick, Mohlamonyane Mbali, Morolo Matshidiso, Nonyane Bareng Aletta Sanny, Ahmed Khatija, Martinson Neil, Hanrahan Colleen F, Omar Shaheed V, Mathema Barun, Dowdy David W

Abstract excerpt

BACKGROUND: Whole genome sequence data can generate insights about Mycobacterium tuberculosis (Mtb) transmission. We used whole genome sequencing and linked epidemiology data from a recent randomized trial to characterize Mtb relatedness across 3 geographically distinct South African sites. METHODS: We sequenced culture isolates from participants with culture-positive tuberculosis in the Kharituwe study, which...

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Identifiers

PMID: 40576365
DOI: 10.1093/infdis/jiaf326
PMCID: PMC12526890

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