Article

Pluripotent Stem Cell-derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

2018-11-04

Abstract excerpt

<h4>SUMMARY</h4> The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain. Here, we report oligodendrogenesis in forebrain organoids, generated by using OLIG2-GFP knockin human pluripotent stem cell (hPSC) reporter lines. OLIG2/GFP exhibits distinct temporal expression patterns...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a20aa4e-f2a8-5109-a3d5-0ed32881b454
DOI: 10.1101/460907

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pluripotent Stem Cell-derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral OriginsDOI 10.1101/460907Read

Generation of human cerebral organoids with a structured outer subventricular zoneSemantic proximity Read

Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous systemSemantic proximity Read

Rapid and efficient oligodendrocyte differentiation from human pluripotent stem cells via dual inhibition of BMP and Notch signalingSemantic proximity Read

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissueSemantic proximity Read

Rapid and efficient generation of human oligodendrocytes myelinating adult human cortical neuronsSemantic proximity Read

Brain regional identity and cell type specificity landscape of human cortical organoid modelsSemantic proximity Read

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signaturesSemantic proximity Read

Unraveling Lineage Roadmaps and Cell Fate Determinants to Postnatal Neural Stem Cells and Ependymal cells in the Developing Ventricular ZoneSemantic proximity Read

Modeling cerebral development <i>in vitro</i> with L- <i>MYC</i> -immortalized human neural stem cell-derived organoidsSemantic proximity Read

Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic InjurySemantic proximity Read

Generation of Bioengineered Neuronal Organoids (BENOs) from human pluripotent stem cellsSemantic proximity Read

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem CellsSemantic proximity Read