Article

Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases

2022-04-08

Abstract excerpt

<h4>Background</h4> Genome wide association studies (GWAS) have identified and validated more than 200 genomic loci associated with the inflammatory bowel disease (IBD), although for most the causal gene remains unknown. Given the importance of myeloid cells in IBD pathogenesis, the current study aimed to uncover the role of genes within IBD genetic loci that are endogenously expressed in this cell lineage. <h4>M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d45ef87-461c-504f-9db8-aa933a39d446
DOI: 10.1101/2022.04.06.487252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel DiseasesDOI 10.1101/2022.04.06.487252Read

Functional screen of Inflammatory bowel disease genes reveals key epithelial functionsSemantic proximity Read

Inflammatory Gene Panel Guiding the Study of Genetics in Inflammatory Bowel Disease.Semantic proximity Read

Identification of Novel Drug Target Genes in Inflammatory Bowel Disease through Mendelian Randomization Study and Single-Cell AnalysisSemantic proximity Read

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.Semantic proximity Read

The proinflammatory role of guanylate binding protein 5 in inflammatory bowel diseasesSemantic proximity Read

Screening of pathogenic genes of ulcerative colitis and colorectal cancer by integrated bioinformatics analysisSemantic proximity Read

Genomics and proteomics: implications for inflammatory bowel diseases.Semantic proximity Read

Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease TissueSemantic proximity Read

A collection of patient-derived intestinal organoid lines reveals epithelial pheno-types associated with genetic drivers of pediatric inflammatory bowel diseaseSemantic proximity Read

GWA studies: rewriting the story of IBD.Semantic proximity Read

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology.Semantic proximity Read

Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.Semantic proximity Read