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Article

Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population.

Human genomics - 25 Mar 2024

Goljan Ewa, Abouelhoda Mohammed, Tahir Asma, ElKalioby Mohamed, Meyer Brian, Monies Dorota

Abstract excerpt

BACKGROUND: SLCO1B1 plays an important role in mediating hepatic clearance of many different drugs including statins, angiotensin-converting enzyme inhibitors, chemotherapeutic agents and antibiotics. Several variants in SLCO1B1 have been shown to have a clinically significant impact, in relation to efficacy of these medications. This study provides a comprehensive overview of SLCO1B1 variation in Saudi...

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Drug Transport and Resistance Mechanisms
Genetic Associations and Epidemiology
High-Throughput Nucleotide Sequencing
Liver-Specific Organic Anion Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parathyroid Disorders and Treatments

Pharmacogenetics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 38523294
DOI: 10.1186/s40246-024-00594-9
PMCID: PMC10962151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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