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Article

Prevalence, mutational spectrum and clinical implications of clonal hematopoiesis of indeterminate potential in plasma cell dyscrasias.

Seminars in oncology - 1 Dec 2022

Testa Stefano, Kumar Jyoti, Goodell Alex J, Zehnder James L, Alexander Kevin M, Sidana Surbhi, Arai Sally, Witteles Ronald M, Liedtke Michaela

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is common both in healthy individuals and patients with hematological cancers. Recent studies have showed worse prognosis for patients with multiple myeloma (MM) and non-Hodgkin lymphoma undergoing stem cell transplant, that have concomitant presence of CHIP. Data regarding the clinical and biological role of CHIP in plasma cell dyscrasias (PCDs) is rapidly...

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PMID: 36503855
DOI: 10.1053/j.seminoncol.2022.11.001

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