Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy

1 Jan 2010

Abstract excerpt

Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20811597
DOI: 10.4061/2010/920161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer TherapyPMID 20811597Read ↗

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing RadiationSemantic proximity Read ↗

Genome Instability and γH2AX.Semantic proximity Read ↗

Histone Phosphorylation in DNA Damage ResponseSemantic proximity Read ↗

Histone Phosphorylation in DNA Damage ResponseSemantic proximity Read ↗

Activation of DNA damage response signaling in mammalian cells by ionizing radiationSemantic proximity Read ↗

Focus on histone variant H2AX: to be or not to be.Semantic proximity Read ↗

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.Semantic proximity Read ↗

Kinetics of nuclear phosphorylation ( -H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin CSemantic proximity Read ↗

H2AX: the histone guardian of the genome.Semantic proximity Read ↗

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responsesSemantic proximity Read ↗

γH2AX, an Accurate Marker That Analyzes UV Genotoxic Effects on Human Keratinocytes and on Human SkinSemantic proximity Read ↗

Validation of a flow cytometry‐based detection of γ‐H2AX, to measure DNA damage for clinical applicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.