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Article

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics.

Biology open - 15 Feb 2021

Schmid Manuel, Toepfer Christopher N

Abstract excerpt

The fundamental basis of muscle contraction 'the sliding filament model' (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954) and the 'swinging, tilting crossbridge-sliding filament mechanism' (Huxley, 1969; Huxley and Brown, 1967) nucleated a field of research that has unearthed the complex and fascinating role of myosin structure in the regulation of contraction. A recently discovered energy conserving state...

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Source

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Identifiers

PMID: 33589442
DOI: 10.1242/bio.057646
PMCID: PMC7904003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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