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Article

Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells.

Cell chemical biology - 20 Mar 2025

Bhattacharya Swarnabh, Shivdasani Ramesh A

Abstract excerpt

Differentiated progenitors in intestinal crypts react to stem cell attrition by reverting to the multipotent state. In the February issue of Nature Cell Biology, Pashos et al.1 reveal a role for H3K36 methylation at cell-type-restricted genes in helping maintain differentiated cell states, hence regulating cell plasticity and regenerative responses.

Read the complete abstract on PubMed

Topics

Epigenesis, Genetic
Humans
Epithelial Cells
Histones
Intestinal Mucosa
Animals
Cell Differentiation
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Methylation

Source

Identifiers

PMID: 40118045
DOI: 10.1016/j.chembiol.2025.02.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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