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Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumours

18 Mar 2025

Abstract excerpt

BACKGROUND: Primary cutaneous melanocytic tumours harbouring MAP2K1 mutations without second-hit genomic alterations represent a subclass of neoplasms with poorly understood biological behaviour. This study aimed to investigate the clinical outcomes and genomic characteristics of these tumours. METHODS: This cohort study included primary cutaneous melanocytic tumours with MAP2K1 mutations from patients at two...

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PMID: 40107205
DOI: 10.1016/j.ebiom.2025.105643

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