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Article

Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors With Activating Mutations in MAP2K1.

The American journal of surgical pathology - 1 Dec 2023

Fumero-Velázquez Mónica, Hagstrom Michael, Dhillon Soneet, Geraminejad Tara, Olivares Shantel, Donati Michele, Nosek Daniel, Waldenbäck Pia, Kazakov Dmitry, Sheffield Brandon S, Tron Victor A, Gerami Pedram

Abstract excerpt

Activating mutations in MAP2K1 can be seen in benign and intermediate-grade melanocytic neoplasms with spitzoid morphology. We analyzed the clinical, histopathologic, and genetic features for 16 cases of benign and intermediate-grade melanocytic tumors harboring activating MAP2K1 mutations. We compared them to Spitz neoplasms with characteristic Spitz fusions or HRAS mutation. We also compared the mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37773074
DOI: 10.1097/PAS.0000000000002131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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