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Article

Spatial distribution and activation changes of T cells in pancreatic tumors according to KRAS mutation subtype

14 Mar 2025

Abstract excerpt

To enhance immunotherapy efficacy in pancreatic cancer, it is crucial to characterize its immune landscape and identify key factors driving immune alterations. To achieve this, we quantitatively analyzed the immune microenvironment using multiplex immunohistochemistry, assessing the spatial relationships between immune and tumor cells to correlate with patient survival rates and oncological factors. Additionally,...

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Identifiers

PMID: 40090570
DOI: 10.1016/j.canlet.2025.217641

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