Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mediterranean and low-fat diets are equally effective in MASLD resolution at 12 weeks regardless of PNPLA3 genotype: A randomized controlled trial.

Hepatology communications - 1 Dec 2025

Dogay Us Gediz, Innocenti Francesco, Koc Ozgur Muhammet, Alagoz Ayse Eylul, Yumuk Volkan Demirhan, Gungor Zeynep Banu, Koek Ger H

Abstract excerpt

BACKGROUND: Dietary interventions are key for managing metabolic dysfunction-associated steatotic liver disease (MASLD), yet optimal diets and the role of PNPLA3 in modulating response to diet remain unclear. We evaluated the efficacy of a Mediterranean diet (MD) versus a low-fat diet (LFD) on hepatic fat and fibrosis, assessing interactions with PNPLA3 genotype. METHODS: Two hundred fifty adults with MASLD with...

Read the complete abstract on PubMed

Topics

Humans
Lipase
Male
Female
Middle Aged
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Membrane Proteins

Diet, Mediterranean

Adult

Diet, Fat-Restricted

Polymorphism, Single Nucleotide

Treatment Outcome

Fatty Liver

Acyltransferases

Phospholipases A2, Calcium-Independent

Source

Open in PubMed Open full text

Identifiers

PMID: 41284948
DOI: 10.1097/HC9.0000000000000856
PMCID: PMC12657048

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mediterranean and low-fat diets are equally effective in MASLD resolution at 12 weeks regardless of PNPLA3 genotype: A randomized controlled trial.PMID 41284948Read ↗

PNPLA3 gene variation modulates diet-induced improvement in liver lipid content in type 2 diabetes.Semantic proximity Read ↗

A nutrigenetic precision approach for the management of non-alcoholic fatty liver disease.Semantic proximity Read ↗

Patatin-like phosphatase domain-containing 3 genotype and quality of dietary fat modify the liver adiposity in men.Semantic proximity Read ↗

Patatin-like phosphatase domain-containing 3 genotype and quality of dietary fat modify the liver adipositySemantic proximity Read ↗

Weight Loss-Induced Metabolic Remodeling in Metabolic dysfunction-associated steatotic liver disease: A Cohort Study Stratified by Genetic Risk.Semantic proximity Read ↗

Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population.Semantic proximity Read ↗

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver diseaseSemantic proximity Read ↗

<i><scp>PNPLA</scp>3</i> gene polymorphism accounts for fatty liver in community subjects without metabolic syndromeSemantic proximity Read ↗

PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.Semantic proximity Read ↗

PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

A Very Low-Carbohydrate Program in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease and Phospholipase Domain-Containing Protein 3 Risk Genotype: Pre-Post Intervention Study.Semantic proximity Read ↗

Feasibility, Advantages and Future Perspectives of Milpa Diet for MASLD in Mesoamerican PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.