Role of Patatin-Like Phospholipase Domain-Containing 3 Gene for Hepatic Lipid Content and Insulin Resistance in Diabetes.

doi:10.2337/dc20-0329

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Article

Role of Patatin-Like Phospholipase Domain-Containing 3 Gene for Hepatic Lipid Content and Insulin Resistance in Diabetes.

Diabetes care - 1 Sept 2020

Zaharia Oana P, Strassburger Klaus, Knebel Birgit, Kupriyanova Yuliya, Karusheva Yanislava, Wolkersdorfer Martin, Bódis Kálmán, Markgraf Daniel F, Burkart Volker, Hwang Jong-Hee, Kotzka Jörg, Al-Hasani Hadi, Szendroedi Julia, Roden Michael

Abstract excerpt

OBJECTIVE: The rs738409(G) single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene associates with increased risk and progression of nonalcoholic fatty liver disease (NAFLD). As the recently described severe insulin-resistant diabetes (SIRD) cluster specifically relates to NAFLD, this study examined whether this SNP differently associates with hepatic lipid content...

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PMID: 32910776
DOI: 10.2337/dc20-0329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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