Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial.

doi:10.1093/jn/nxac046

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Article

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial.

The Journal of nutrition - 6 Jul 2022

Schmidt Kelsey A, Jones Roshonda B, Rios Claudia, Corona Yesica, Berger Paige K, Plows Jasmine F, Alderete Tanya L, Fogel Jennifer, Hampson Hailey, Hartiala Jaana A, Cai Zhiheng, Allayee Hooman, Nayak Krishna S, Sinatra Frank R, Harlan Gregory, Pickering Trevor A, Salvy Sarah-Jeanne, Mack Wendy Jean, Kohli Rohit, Goran Michael I

Abstract excerpt

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) among Latinos is partially attributed to a prevalent C>G polymorphism in the patatin-like phospholipase 3 (PNPLA3) gene. Cross-sectional analyses in Latino children showed the association between dietary sugar and liver fat was exacerbated by GG genotype. Pediatric feeding studies show extreme sugar restriction improves liver fat, but no prior trial has...

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Identifiers

PMID: 35218194
DOI: 10.1093/jn/nxac046
PMCID: PMC9258557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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