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Article

PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.

Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2025

Speliotes Elizabeth K, Schneider Carolin Victoria

Abstract excerpt

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects up to 30% of Western populations. While obesity is a recognized risk factor, MASLD does not develop in all obese individuals, highlighting the need to understand genetic and environmental interactions. The PNPLA3 I148M variant has been identified as a key genetic risk factor, significantly increasing the likelihood of MASLD...

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Acyltransferases
Diet
Exercise
Fatty Liver
Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phospholipases A2, Calcium-Independent

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Identifiers

PMID: 39559944
DOI: 10.1111/liv.16106
PMCID: PMC11815600

Genes

PNPLA3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.PMID 39559944Read ↗

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