The neutrophil antigen 3a/b polymorphism in SLC44A2 unexpectedly encodes the Csa/Csb red cell antigens.

doi:10.1182/blood.2024026285

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The neutrophil antigen 3a/b polymorphism in SLC44A2 unexpectedly encodes the Csa/Csb red cell antigens.

Blood - 10 Jul 2025

Duval Romain, Soudry Alissa, De Oliveira Rios Jonathan, Linguet Sarah Liane, Taillepierre Miguel, Matesic Graziella, Raneri Alexandre, Laiguillon Guy, Le Toriellec Emilie, Gautier Emilie-Fleur, Vainqueur Damien, Babinet Jérôme, Masson Cécile, Gelly Jean Christophe, Le Van Kim Caroline, Romana Marc, Chen Dawei, Santoso Sentot, Koehl Berengere, Peyrard Thierry, Azouzi Slim

Abstract excerpt

ABSTRACT: The Csa blood group antigen was identified >50 years ago, but its genetic basis has yet to be elucidated. All our recent genomic investigation has failed to resolve the genetic basis of this enigmatic antigen. By investigating the association of the human neutrophil antigen (HNA)-3a/b polymorphism (rs2288904-G/A) in SLC44A2 with clinical features of sickle cell disease, we incidentally discovered that...

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PMID: 40090003
DOI: 10.1182/blood.2024026285

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SLC44A2

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