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Article

Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System.

International journal of molecular sciences - 1 Apr 2022

Stenfelt Linn, Nilsson Jonas, Hellberg Åsa, Liew Yew Wah, Morrison Jenny, Larson Göran, Olsson Martin L

Abstract excerpt

The Sda histo-blood group antigen (GalNAcβ1-4(NeuAcα2-3)Galβ-R) is implicated in various infections and constitutes a potential biomarker for colon cancer. Sd(a−) individuals (2−4% of Europeans) may produce anti-Sda, which can lead to incompatible blood transfusions, especially if donors with the high-expressing Sd(a++)/Cad phenotype are involved. We previously reported the association of B4GALNT2 mutations with...

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PMID: 35409292
DOI: 10.3390/ijms23073936
PMCID: PMC8999409

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