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Genetic landscape of human neutrophil antigen variants in India from population-scale genomes.

HLA - 1 Mar 2023

Rophina Mercy, Bhoyar Rahul C, Imran Mohamed, Senthivel Vigneshwar, Divakar Mohit Kumar, Mishra Anushree, Jolly Bani, Sivasubbu Sridhar, Scaria Vinod

Abstract excerpt

Antibodies against human neutrophil antigens (HNAs) play a significant role in various clinical conditions such as neonatal alloimmune neutropenia, transfusion-related acute lung injury, and other nonhemolytic transfusion reactions. This study aims to identify the genotype and allele frequencies of HNAs in the healthy Indian population. Ten genetic variants in four human genes encoding alleles of HNAs class I-V...

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PMID: 36502377
DOI: 10.1111/tan.14938

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