Article
Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus.
Brain : a journal of neurology - 19 Apr 2023
Wang Junyang, Liu Jiewei, Li Shiwu, Li Xiaoyan, Yang Jinfeng, Dang Xinglun, Mu Changgai, Li Yifan, Li Kaiqin, Li Jiao, Chen Rui, Liu Yixing, Huang Di, Zhang Zhijun, Luo Xiong-Jian
Abstract excerpt
Genome-wide association studies have identified 10q24.32 as a robust schizophrenia risk locus. Here we identify a regulatory variant (rs10786700) that disrupts binding of transcription factors at 10q24.32. We independently confirmed the association between rs10786700 and schizophrenia in a large Chinese cohort (n = 11 547) and uncovered the biological mechanism underlying this association. We found that...
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