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Article

Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer.

JCI insight - 9 Oct 2023

Pethő Zoltán, Najder Karolina, Beel Stephanie, Fels Benedikt, Neumann Ilka, Schimmelpfennig Sandra, Sargin Sarah, Wolters Maria, Grantins Klavs, Wardelmann Eva, Mitkovski Miso, Oeckinghaus Andrea, Schwab Albrecht

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression triggers pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) to induce PDAC fibrosis. We revealed that alkaline environmental pH was sufficient to induce PSC differentiation to a...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37643024
DOI: 10.1172/jci.insight.170928
PMCID: PMC10619433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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